The quantification of Glutathione ( GSH ) using 1 H - MRS , is possible
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Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy
Glutathione (GSH) is a major antioxidant in humans that is involved in the detoxification of reactive radicals and peroxides. The molecular structural conformations of GSH depend on the surrounding micro-environment, and it has been experimentally evaluated using NMR and Raman spectroscopic techniques as well as by molecular dynamics simulation studies. The converging report indicates that GSH ...
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Localized proton magnetic resonance spectroscopy (H MRS) became an important tool for investigating brain metabolism non-invasively. In animal models, high field H MRS allows detection of almost 20 metabolites [1-4], also called the neurochemical profile (taurine (Tau), creatine (Cr), phosphocreatine (PCr), phosphocholine (PCho), glycerophosphocholine (GPC), glutamate (Glu), glutamine (Gln), my...
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Introduction Antioxidant defenses are involved in protecting against dementia and neurodegenerative disease. Vitamin C (ascorbate) and glutathione (GSH) are the two most concentrated chemical antioxidants in the human central nervous system [1]. While human brain region specific ascorbate concentration ([Asc]) changes have been measured post mortem as a function of age [2], studies in young rat...
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Glutathione (GSH) is one of the most important antioxidants that plays an essential role in detoxification of reactive oxygen species (ROS) which oxidizes to glutathione disulfide (GSSG). Paraquat (PQ), awidely used herbicide, causes pulmonary injury with the productionof ROS. Excessive ROS accumulation as a consequence of PQ exposure are frequently targeted by GSH thereby oxidative stress lead...
متن کاملHigh Performance Liquid Chromatography Coupled with Pre-column Derivatization for Determination of Oxidized Glutathione Level in Rats Exposed to Paraquat
Glutathione (GSH) is one of the most important antioxidants that plays an essential role in detoxification of reactive oxygen species (ROS) which oxidizes to glutathione disulfide (GSSG). Paraquat (PQ), awidely used herbicide, causes pulmonary injury with the productionof ROS. Excessive ROS accumulation as a consequence of PQ exposure are frequently targeted by GSH thereby oxidative stress lead...
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